Prophet Isaac was sent to the people of the Sham area (includes present day Syria, Jordan, Lebanon, and Palestine). God revealed verse 113 of Suratus-Saffat. This verse means that God gave Abraham the good news of the coming of Isaac, and that he would be highly pious. God blessed Abraham, Isaac, and people from their children. God told that among their children were people who were fair to themselves, upright, and some were unfair to themselves and blasphemed. Prophet Ishaq Story,
Isaac's Sons - from Commentators (Prophet Ishaq Story)
The Quran does not give details of Isaac's life (pbuh), but reliable Quranic commentators mentioned that when Abraham felt that his life was drawing to a close, he wished to see Isaac married. He did not want Isaac to marry one of the Canaanites, who were pagans, so he sent a trustworth servant to Haran in Iraq to choose a bride for Isaac. The servant's choice fell upon Rebekah Bint Bethuel, Ibn Nahor (who was a brother of Abraham). Isaac married her and she gave birth to a set of twins, Esau (Al Eis) and Jacob (Yaqub).
I'll feelings developed between the two brothers when they grew into manhood. Esau disliked the fact that Jacob was favoured by his father and by Allah with prophethood. This ill feeling became so searious that Esau threatened to kill his brother. Fearing for his life, Jacob fled the country.
The People of the Book said that when Isaac was forty years old, he married Rebekah Bint Bethuel, during his father's life. They said she was sterile, so Isaac prayed to Allah and then she became pregnant. She gave birth to twin boys. The first one was called Esau whom the Arabs called Al-Eis. He became the father of Rum. The second one was called Jacob, which means Isreal, (belonging to the people of Israel).
Issac's Death (Prophet Ishaq Story)
Jacob came to his father Isaac and settled with him in the village of Hebron which lies in the land of Canaan where Abraham had lived. Then Isaac fell ill and died when he was one hundred eighty years old. His sons Esau and Jacob buried him with his father Abraham Al Khalil in a cave which he had bought. It was said that Abraham died at the age of one hundred seventy five.